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Re: ESBL’s – which ones?

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    Irene Barron
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    Irene Barron

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    Hi
    Regarding this question we isolate all our MDRO’s and ESBL’s and collect data accordingly. We follow the CDC criteria (I work Overseas thus this definition may not quite apply to you but you can look at their reference for some information/clarification)

    Here is a summary of our definition of MDRO and ERSBL for your FYI, Hope it helps

    Gram-negative MDROs: Gram-negative MDROs include Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. To be considered for MDRO criteria, the gram-negative organism should be resistant to all agents in atleast 3 classes. The antimicrobials classes are: – b-lactams (penicilins and cephalosporins), Aminoglycosides, Fluoroquinolones and Carbapenems

    Pseudomonas aeruginosa is considered MDR if resistant to three classes of anti-pseudomonal antibiotics. Cephalosporins (Ceftazidime, Cefepime), Penicillins (Pip/Taz), Carbapenems (Imipenem, Meropenem), Fluroquinolones (Ciprofloxacin, Levofloxacin, Norfloxacin), Aminoglycosides (Amikacin, Gentamicin)

    Acinetobacter is considered MDR if resistant to three classes of antibiotics. Aminoglycosides (Amikacin, Gentamicin), Carbapenems (Imipenem, Mepropenem, Ertapenem), Cephalosporins (Cefotaxime, Ceftazidime, Cefepime), B-lactam beta lactamase inhibitors (Amox/ Kclav, Pip/Taz), Fluroquinolones (Ciprofloxacin, Levofloxin, Moxifloxacin, Norfloxacin)

    An isolate with intermediate sensitivity, will be considered resistant.
    The isolate has to be resistant to all agents in a class.
    S. maltophilia is MDR if resistant to cotrimoxazole.

    Gram-positive MDROs:Gram-positive MDROs include MRSA and VRE.

    Cheers
    Irene Barron
    IC Coordinator

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